Setting it up is easy and intuitive. The only downside is the front-end styling. Nothing that can't be corrected by your own stylesheets.
One thing is still missing, though: Translations/Multi-Language support.
This absolutely rocks.
I recommend using the Advanced image manager plug-in, too, which adds a neat Lightbox and advanced image handling (e.g. text floating around images etc.) options.
It does what it says, no worrying about having to publish or organize your images - just upload it to your directory, but one simple line in your article and there you go!
I built a large gallery using joomla content section and categorys with articles being the gallery directorys. I works flawlessly and very simple!
The only thing I wish the free version should have added once, is pagination for really large folders! Add this, and it will be an 5stars plug-in!
Though not as many options as sh404sef, this is definitely worth a look! I use it on one of my private sites (A community site) and it worked flawless. Though I do not recommend this free version for commercial sites due to the Copyright tag. (In the paid version it is possible to disable the tag)
There are even some nice goodies like PicLens support or various ways to display the full images in the gallery component, as well as some extra modules and plugins (The Random Image module is just great!)
All I wish to be added some day is the ability to have a "auto-size" lightbox which adjusts according to the image resolution instead of a fixed lightbox size.
This works almost flawless, even in this early Alpha stadium, on my private Community Site. Very brilliant, and I will definitely donate to it!