When it comes to send hundreds or thounsands of mails: I prefer Avymailing. It is a rich extension offers a wide variety of functions but is still easy to use and helpful. Also I would like to thank the support who seems to be online 24 hours a day and 7 days a week. Just perfect! Thank you.
... every time I setup a Joomla! install: Install Akeeba Backup! Easy to install, easy to use. And if things happen ... and anything went wrong: Akeeba Backup helps you out. Perfect. Thank you for this component.