The setup is easy. It all flows very well and is easy to understand.
The customization is fantastic as well. They have front side changes to the language file, but they also tell you how to change something in the code.
Support is top notch. I just installed this with the Rocket Theme extensions and something didn't jive. They fixed the issue for me after I posted a support thread about an hour before (they would have had it faster had I emailed them the login details).
The front end is easy for my employees to navigate. This is a huge plus.
Unlike some of the other stand alone CRMS, my employees would have had a hard time navigating around. It needs to be simple for them, and fast. While they are doing the day to day operations on the phone, our system needs to keep up with their work.
Cons: The only con that I can see is setting categories for specific items (deals, people). However, I plan on suggesting this in the forums soon. They seem really open to suggestions.